{"id":1338,"date":"2026-09-28T05:17:40","date_gmt":"2026-09-28T05:17:40","guid":{"rendered":"https:\/\/www.digitalizedera.com\/bio-mimetic\/?page_id=1338"},"modified":"2026-09-30T05:27:07","modified_gmt":"2026-09-30T05:27:07","slug":"scientific-resources","status":"publish","type":"page","link":"https:\/\/www.digitalizedera.com\/bio-mimetic\/scientific-resources\/","title":{"rendered":"Scientific Resources"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1338\" class=\"elementor elementor-1338\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-45a57a9f e-con-full e-flex e-con e-parent\" data-id=\"45a57a9f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2694882b elementor-widget elementor-widget-page-title\" data-id=\"2694882b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"page-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\n\t\t<div class=\"hfe-page-title hfe-page-title-wrapper elementor-widget-heading\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.digitalizedera.com\/bio-mimetic\">\n\t\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\n\t\t\t\t\t\t\t\t\n\t\t\t\tScientific Resources  \n\t\t\t<\/h2 > \n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20698db0 elementor-widget elementor-widget-hfe-breadcrumbs-widget\" data-id=\"20698db0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"hfe-breadcrumbs-widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<nav aria-label=\"Breadcrumb\"><ul class=\"hfe-breadcrumbs hfe-breadcrumbs-show-home\"><li class=\"hfe-breadcrumbs-item hfe-breadcrumbs-first\"><span class=\"hfe-breadcrumbs-home-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-home\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M280.37 148.26L96 300.11V464a16 16 0 0 0 16 16l112.06-.29a16 16 0 0 0 15.92-16V368a16 16 0 0 1 16-16h64a16 16 0 0 1 16 16v95.64a16 16 0 0 0 16 16.05L464 480a16 16 0 0 0 16-16V300L295.67 148.26a12.19 12.19 0 0 0-15.3 0zM571.6 251.47L488 182.56V44.05a12 12 0 0 0-12-12h-56a12 12 0 0 0-12 12v72.61L318.47 43a48 48 0 0 0-61 0L4.34 251.47a12 12 0 0 0-1.6 16.9l25.5 31A12 12 0 0 0 45.15 301l235.22-193.74a12.19 12.19 0 0 1 15.3 0L530.9 301a12 12 0 0 0 16.9-1.6l25.5-31a12 12 0 0 0-1.7-16.93z\"><\/path><\/svg><\/span><a href=\"https:\/\/www.digitalizedera.com\/bio-mimetic\"><span class=\"hfe-breadcrumbs-text\">Home<\/span><\/a><\/li><\/ul><\/nav>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-244ec65 e-con-full e-flex e-con e-parent\" data-id=\"244ec65\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-a433b46 e-con-full e-flex e-con e-child\" data-id=\"a433b46\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-cc75d19 e-con-full e-flex e-con e-child\" data-id=\"cc75d19\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce53996 elementor-widget elementor-widget-heading\" data-id=\"ce53996\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bio-Mimetic Chromatography and in vivo drug distribution <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-18b2c12 e-con-full prfincipul_chromo e-flex e-con e-child\" data-id=\"18b2c12\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f233a9f video_sect elementor-widget elementor-widget-ucaddon_blox_play_button\" data-id=\"f233a9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ucaddon_blox_play_button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Video Play Button -->\n\t\t<link id='font-awesome-css' href='https:\/\/www.digitalizedera.com\/bio-mimetic\/wp-content\/plugins\/unlimited-elements-for-elementor\/assets_libraries\/font-awesome6\/fontawesome-all.min.css' type='text\/css' rel='stylesheet' >\n\t\t<link id='font-awesome-4-shim-css' href='https:\/\/www.digitalizedera.com\/bio-mimetic\/wp-content\/plugins\/unlimited-elements-for-elementor\/assets_libraries\/font-awesome6\/fontawesome-v4-shims.min.css' type='text\/css' rel='stylesheet' >\n\t\t<link id='lity-css' href='https:\/\/www.digitalizedera.com\/bio-mimetic\/wp-content\/plugins\/unlimited-elements-for-elementor\/assets_libraries\/lity\/lity.min.css' type='text\/css' rel='stylesheet' >\n\n<style>\/* widget: Video Play Button *\/\n\n#uc_blox_play_button_elementor_f233a9f{\n width:100%;\n}\n\n.container_uc_blox_play_button_elementor_f233a9f{\n  display: flex;\n  justify-content: center;\n}\n\n#uc_blox_play_button_elementor_f233a9f a{\n  display:inline-block;\n  transition:0.5s;\n  text-decoration:none;\n}\n\n.ue_play_button{\n  text-align:center;\n}\n\n#uc_blox_play_button_elementor_f233a9f a:hover{\n  transform:scale(1.1,1.1);\n}\n\n#uc_blox_play_button_elementor_f233a9f a span.video-button{\n  display:inline-block;\n  align-items: center;\n  justify-content: center;\n  flex-direction: column; \n  display:flex;\n  position:relative;\n  transition:0.3s;\n  line-height:1em;\n}\n\n.ue-play-bg{\n  background-size:cover;\n  background-position:center;\n  background-repeat:none;\n  max-width:100%; \n}\n\n#uc_blox_play_button_elementor_f233a9f a span.video-button svg{\n  height:1em;\n  width:1em;\n}\n\n#uc_blox_play_button_elementor_f233a9f i{\n  vertical-align:middle;\n  transition:0.3s;\n}\n\n#uc_blox_play_button_elementor_f233a9f a span:before{\n  content: '';\n    display: inline-block;\n    position: absolute;\n    top: -2px;\n    left: -2px;\n    bottom: -2px;\n    right: -2px;\n    border-radius: inherit;\n    border: 1px solid #0B1196;\n    -webkit-animation: btnIconRipple 2s cubic-bezier(0.23, 1, 0.32, 1) both infinite;\n    animation: btnIconRipple 2s cubic-bezier(0.23, 1, 0.32, 1) both infinite;\n    border-color: #0B1196;\n}\n\n@keyframes btnIconRipple {\n  0% {\n    border-width: 4px;\n            transform: scale(1);\n  }\n  80% {\n    border-width: 1px;\n            transform: scale(1.35);\n  }\n  100% {\n    opacity: 0;\n  }\n}\n\n\n\n\n\n.lity-close{\n  display: flex;\n  align-items: center;\n  justify-content: center;\n 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class=\"video-button\">\n          <i class='fas fa-play'><\/i>\n  <\/span>  \n<\/a>\n<\/div>\n\n<!-- end Video Play Button -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1617c18 elementor-widget elementor-widget-image\" data-id=\"1617c18\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"480\" height=\"360\" src=\"https:\/\/www.digitalizedera.com\/bio-mimetic\/wp-content\/uploads\/2026\/09\/download-7.jpg\" class=\"attachment-large size-large wp-image-1911\" alt=\"\" srcset=\"https:\/\/www.digitalizedera.com\/bio-mimetic\/wp-content\/uploads\/2026\/09\/download-7.jpg 480w, https:\/\/www.digitalizedera.com\/bio-mimetic\/wp-content\/uploads\/2026\/09\/download-7-300x225.jpg 300w\" sizes=\"(max-width: 480px) 100vw, 480px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-202e99b e-con-full e-flex e-con e-child\" data-id=\"202e99b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5c6778a e-con-full e-flex e-con e-child\" data-id=\"5c6778a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-de5e10d elementor-widget elementor-widget-heading\" data-id=\"de5e10d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The Problem<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cfd5bfc elementor-widget elementor-widget-text-editor\" data-id=\"cfd5bfc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A major concern for the pharmaceutical industry is the high attrition rate (&gt;90 per cent) of potential drug molecules failing during late stages of the drug discovery process. This may be due to lack of efficacy in the clinic, unexpected side effects or unfavourable pharmacokinetics.<br \/><br \/>There is a need for new tools to predict the in vivo distribution of discovery compounds earlier in the drug discovery process, thus reducing the investment in molecules failing unexpectedly in later, more expensive stages of the drug development. There are many in silico prediction tools for estimating pharmaco-kinetic and toxicological effects of compounds based on their chemical structures or physico-chemical properties<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-150ad42 e-con-full e-flex e-con e-child\" data-id=\"150ad42\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7e6c78f elementor-widget elementor-widget-heading\" data-id=\"7e6c78f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Volume distribution and its uses<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b9f5ad elementor-widget elementor-widget-text-editor\" data-id=\"4b9f5ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The volume of distribution reveals how a drug molecule distributes between the plasma and tissue compartment, but it does not provide information on how the compound distributes between various tissues.<br \/><br \/>For drugs that are designed to go to the brain for the required pharmacological effect, we would prefer high brain tissue accumulation together with high free brain concentration. For drugs designed to cure lung diseases for example, we would prefer that the compounds partition preferentially into the lung. Different tissues contain various amounts and types of proteins and phospholipids. Therefore, we can assume that an appropriate combination of the biomimetic binding properties show good correlation with various tissue binding data.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8de8c61 e-con-full e-flex e-con e-child\" data-id=\"8de8c61\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-067463e e-con-full e-flex e-con e-child\" data-id=\"067463e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6057cb7 elementor-widget elementor-widget-heading\" data-id=\"6057cb7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bio-mimetic vs Octanol\/Water<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a36e2e8 elementor-widget elementor-widget-text-editor\" data-id=\"a36e2e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Based on the Abraham solvation equation approach octanol\/water log P has very similar solvation equation to phospholipid (IAM) and albumin (HSA) binding for neutral compounds. They all have very little sensitivity towards H-bond acidity of the molecules. However, the log P model fails for ionisable compounds. Lipophilicity (log D) drops for ionized compounds regardless whether the type of charge is positive or negative. \u00a0Phospholipid binding remains strong for positively charged compounds while albumin binding remains strong for negatively charged compounds.<\/p><p>The type of charge on the molecule at physiological pH drives a compound\u2019s distribution between the plasma and tissues. Bio-mimetic chromatographic measurements of IAM and HSA bindings are more informative than log D. See comparison of logP\/D with bio-mimetic properties.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03d5cdd e-con-full e-flex e-con e-child\" data-id=\"03d5cdd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c779842 elementor-widget elementor-widget-heading\" data-id=\"c779842\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Useful Presentations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e0205b elementor-widget elementor-widget-ucaddon_uc_material_bullets\" data-id=\"9e0205b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ucaddon_uc_material_bullets.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<!-- start Icon Bullets -->\n\n<style>\/* widget: Icon Bullets *\/\n\n\n\n#uc_uc_material_bullets_elementor_9e0205b *{\n\t-webkit-box-sizing: border-box;\n\t-moz-box-sizing: border-box;\n\tbox-sizing: border-box;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .ue-icon-wrapper{\n\tdisplay: flex;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .ue-icon{\n  display:flex;\n  align-items:center;\n  justify-content:center;\n  flex-grow:0;\n  flex-shrink:0;\n  line-height:1em;\n  transition:0.3s;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .ue-icon svg{\n  height:1em;\n  width:1em;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .uc_material_bullets_row{\n\tfont-weight:400;\n\toverflow:hidden;\n\tdisplay:flex;\n\tposition:relative;\n\ttext-align:left;\n\twidth:100%;   \n    transition:0.3s;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .uc_material_bullets_row a.ue-item-link{\n  position:absolute;\n  display:block;\n  top:0;\n  right:0;\n  left:0;\n  bottom:0;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .uc_material_bullets_row:last-child{\n\tmargin-bottom:0px !important;\n}\n\n\n#uc_uc_material_bullets_elementor_9e0205b .uc_material_bullets_row {\n\tposition:relative;\n\tvertical-align:middle;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .uc_material_bullets_row .uc_content_box{\n\tdisplay:flex;\n    flex-direction:column;\n    align-items: flex-start;\n    flex-grow:1;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .ue-bullets{\n  display:grid;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .ue-text, \n#uc_uc_material_bullets_elementor_9e0205b .ue-title, \n#uc_uc_material_bullets_elementor_9e0205b .ue-seperator{\n  width:100%;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .ue-seperator-line{\n  display:inline-block;\n  font-size:0px;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .ue-seperator{\n  font-size:0px;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b.uc-remote-parent .uc_material_bullets_row{\n  cursor:pointer;\n}\n\n.ue-title{\n  font-size:21px;\n  margin:0;\n}\n\n#uc_uc_material_bullets_elementor_9e0205b .uc_content_box > *{\n  transition: all .3s;\n}\n\n<\/style>\n\n<div id=\"uc_uc_material_bullets_elementor_9e0205b\" class=\"uc_material_bullets  \"  >   \t\n  <div class=\"ue-bullets uc-items-wrapper\" role=\"list\">\n    <div class=\"uc_material_bullets_row elementor-repeater-item-5770ff8\" role=\"listitem\">\n  <div class=\"ue-icon-wrapper\" role=\"img\" aria-label=\"\">\n    <div class=\"ue-icon\">\n       <i class='fas fa-tv'><\/i>       \t          \n    <\/div>\n  <\/div>\n  \n  <div class=\"uc_content_box uc_ceal\">\n    <div class=\"ue-title\"><\/div>\n    \n    \t\n    \n    <div class=\"ue-text\">Lipophilicity and bio-mimetic properties measured by HPLC to support drug discovery<\/div>\t\n  <\/div>\n      <a href=\"#\" class=\"ue-item-link\"  aria-label=\"\"><\/a>\n  \t\n<\/div>\n<div class=\"uc_material_bullets_row elementor-repeater-item-b90ef2c\" role=\"listitem\">\n  <div class=\"ue-icon-wrapper\" role=\"img\" aria-label=\"\">\n    <div class=\"ue-icon\">\n       <i class='fas fa-tv'><\/i>       \t          \n    <\/div>\n  <\/div>\n  \n  <div class=\"uc_content_box uc_ceal\">\n    <div class=\"ue-title\"><\/div>\n    \n    \t\n    \n    <div class=\"ue-text\">Lipophilicity in drug discovery<\/div>\t\n  <\/div>\n      <a href=\"#\" class=\"ue-item-link\"  aria-label=\"\"><\/a>\n  \t\n<\/div>\n<div class=\"uc_material_bullets_row elementor-repeater-item-11a1bfa\" role=\"listitem\">\n  <div class=\"ue-icon-wrapper\" role=\"img\" aria-label=\"\">\n    <div class=\"ue-icon\">\n       <i class='fas fa-tv'><\/i>       \t          \n    <\/div>\n  <\/div>\n  \n  <div class=\"uc_content_box uc_ceal\">\n    <div class=\"ue-title\"><\/div>\n    \n    \t\n    \n    <div class=\"ue-text\">Comparison of logP\/D with bio-mimetic properties<\/div>\t\n  <\/div>\n      <a href=\"#\" class=\"ue-item-link\"  aria-label=\"\"><\/a>\n  \t\n<\/div>\n\n  <\/div>\n<\/div>\n<!-- end Icon Bullets -->\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce6ef80 elementor-widget elementor-widget-heading\" data-id=\"ce6ef80\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Online courses:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-40b80d1 elementor-widget elementor-widget-button\" data-id=\"40b80d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-video\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M336.2 64H47.8C21.4 64 0 85.4 0 111.8v288.4C0 426.6 21.4 448 47.8 448h288.4c26.4 0 47.8-21.4 47.8-47.8V111.8c0-26.4-21.4-47.8-47.8-47.8zm189.4 37.7L416 177.3v157.4l109.6 75.5c21.2 14.6 50.4-.3 50.4-25.8V127.5c0-25.4-29.1-40.4-50.4-25.8z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Free introductory course<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Scientific Resources Home Bio-Mimetic Chromatography and in vivo drug distribution skip render: ucaddon_blox_play_button The Problem A major concern for the 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