Six chromatographic measurements provide experimentally determined physicochemical and biomimetic properties that are used in 22 models to predict ADMET and in vivo distribution behaviour.

• Sample requirement: 50 µL of 10 mM DMSO solution per compound (or approx. 1 mg solid).
• No chemical structure is required for standard measurements & predictions.
• Results are confidential and include measured & derived data, calibration info, and scientific interpretation.
• Secure storage & sharing available via CDD Vault.
• Standard turnaround: 10 working days from sample receipt.
• Scientific Q&A and discussion of results included.

For organisations wishing to establish biomimetic HPLC measurements internally, we provide validated calibration mixtures, experimental protocols and technical support for setting up the methods.

We can also provide an Excel-based high-throughput data-processing tool for converting chromatographic retention data into calibrated biomimetic property values.

Support includes method implementation, system suitability, troubleshooting and ongoing technical advice.

Training is available for scientists who want to understand not only how measurements are performed, but what resulting data mean and how they can be used for compound selection and optimisation in early drug discovery.

When chemical structures are provided, we go beyond property measurement to help project teams interpret structure–property relationships.

Measured biomimetic and physicochemical properties are considered alongside chemical structure to identify drivers of unfavourable distribution behaviour and suggest structural modifications for a more favourable profile.